|
KMID : 0391520150230030118
|
|
Journal of the Korean Child Neurology Society
2015 Volume.23 No. 3 p.118 ~ p.123
|
|
|
Paradigm Shift to Spinal Magnetic Resonance Imaging the Diagnosis of Guillain-Barre Syndrome in Children
|
|
Kim Jung-Eun
Baek Hee-sun
Ahn Ji-Young
Hwang Su-Kyeong
Kim Yong-Sun
Seo Hye-Eun
Kwon Soon-Hak
|
|
|
Abstract
|
|
|
Purpose: This study was aimed to evaluate the clinical value of gadoliniumenhanced
spinal magnetic resonance imaging (MRI) in the diagnosis of Guillain-
Barre syndrome (GBS) by comparing it with cerebrospinal fluid (CSF) and nerve
conduction studies (NCS) in children.
Method: A single center, retrospective analysis of clinical investigations undertaken in
children with GBS over a 5-year period was performed. The patients’ respective medical
records, including spinal MRIs and nerve conduction studies, were reviewed.
Results: A total of seventeen children (mean age 5.3±3.6 years; males, 12, females, 5)
were enrolled in the study. Twelve out of 17 children (71%) showed gadolinium nerve
root enhancement, mostly anterior along with posterior roots (10/12, 83%) at 4.1 days
of illness, compared to CSF (2/11, 11%) at 2.5 days and NCS (11/17, 64%) at 7.4 days
of illness (P<0.05). In addition, it appeared the more severe symptoms showed more
positive findings; however, the difference was statistically insignificant (P>0.05).
Conclusion: In conclusion, NCS are a standard diagnostic tool for GBS. This study
supports the gadolinium-enhanced spinal MRI as a valuable investigating technique
in the early diagnosis of GBS, although it is not necessarily superior. However,
further studies are needed to elucidate the mechanisms and to strengthen the
results.
|
|
|
KEYWORD
|
|
|
Guillain-Barre syndrome, magnetic resonance imaging, diagnosis, child
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|